About Us  |  Contact Us  |  Español
Memorial Hospital
cne_uplefticon
Care New England
 
    Health Library
    Find A Doctor
Search by Last Name
Search by Specialty
Search by CNE Affiliation*
Search by Keyword
 
Limit Search Results By
Gender
Languages

Fibrate Drugs

Drugs in the fibrate family are used to improve levels of cholesterol and related lipids found in the blood. Fibrates are particularly helpful for individuals with high levels of triglycerides.
Medications in this category include:
  • Clofibrate (Atromid-S)
  • Gemfibrozil (Lopid)
  • Fenofibrate (Tricor)
Fibrate drugs are known to raise homocysteine levels in the blood. High levels of homocycsteine have been associated with increased risk of heart disease, although a direct connection has not been proven.
In a double-blind, placebo controlled trial of 29 men taking fenofibrate, use of the B-vitamins folate (650mcg), vitamin B12 (50mcg) and vitamin B6 (50mg) once daily for 6 weeks restored homocysteine levels to nearly normal values. 1
Fibrate drugs are known to increase the "blood thinning" effects of drugs in the warfarin (Coumadin) family. Certain herbs, such as garlic, danshen, devil’s claw, dong quai, papaya, PC-SPES and red clover, may thin the blood in a manner somewhat similar to warfarin. Although no such interactions have yet been reported, it is at least theoretically possible that combined use of these herbs and fibrate drugs could pose a risk of bleeding problems.

References

1 Dierkes J, Westphal S, Kunstmann S, et al. Vitamin supplementation can markedly reduce the homocysteine elevation induced by fenofibrate. Atherosclerosis . 2001;158:161-164.

Revision Information

Memorial Hospital
© 2011 Site Index | Disclaimer | Legal Notices | Talks Your Health