About Us  |  Contact Us  |  Español
Care New England Health System
cne_uplefticon
Care New England
 
    Health Library
    Find A Doctor
Search by Last Name
Search by Specialty
Search by CNE Affiliation*
Search by Keyword
 
Limit Search Results By
Gender
Languages

Isotretinoin

The drug isotretinoin (Accutane) is related to vitamin A. It is used to treat severe acne.
Trade Name: Accutane
Vitamin A
Both vitamin A and isotretinoin can cause toxic symptoms if taken in excess. It is presumed likely that simultaneous use of vitamin A and isotretinoin would tend to amplify the risk. For this reason, people using isotretinoin should not take vitamin A at doses higher than the recommended daily allowance; in fact, because most people get enough vitamin A from the diet, it might be preferable to take no vitamin A supplements at all. (Supplements that use beta-carotene to supply vitamin A are probably safe.)
St. John’s Wort
Because isotretinoin can cause birth defects, women who use it are often advised to take oral contraceptives (birth control pills). The herb St. John’s wort is thought to interact with birth control pills and reduce their effectiveness, raising the risk of pregnancy. 1-3 For this reason, people taking accutane and oral contraceptives should avoid using St. John’s wort.
Vitamin E
One preliminary study hints that vitamin E might reduce side effects of isotretinoin. 4

References

1 Murphy PA, Kern SE, Stanczyk FZ, et al. Interaction of St. John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. Contraception . 2005;71:402–8.

2 Pfrunder A, Schiesser M, Gerber S, et al. Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial. Br J Clin Pharmacol . 2003;56:683–90.

3 Gorski JC, Hamman MA, Wang Z, et al. The effect of St. John's Wort on the efficacy of oral contraception. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, March 24-27, 2002, Atlanta, GA; abstract MPI-80.

4 Dimery IW, Hong WK, Lee JJ, et al. Phase I trial of alpha-tocopherol effects on 13-cis-retinoic acid toxicity. Ann Oncol 1997;8:85–9.

Revision Information

Care New England Health System
© 2011 Site Index | Disclaimer | Legal Notices | Talks Your Health