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Hairy Cell Leukemia

(HCL; Leukemic Reticuloendotheliosis)

Definition

Hairy cell leukemia (HCL) is a rare form of cancer. It involves white blood cells called B lymphocytes. White blood cells protect the body from infection. HCL gets its name from the tiny hair-like projections that stick out of the surface of these cancer cells. Illness results from the build up of these cancer cells in the bone marrow and spleen.
White Blood Cells
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Causes

The exact cause of HCL is unknown.

Risk Factors

HCL occurs more often in men. It also occurs more often in people over the age of 50.

Symptoms

HCL usually develops slowly over time. Early on, there may not be any symptoms. The cancer cells eventually overgrow the bone marrow. This affects the growth of normal cells such as red blood cells and platelets.
Symptoms may include:
  • Abdominal swelling
  • Fever
  • Easy bruising
  • Night sweats
  • Swollen lymph nodes

Diagnosis

You will be asked about your symptoms and medical history. A physical exam will be done.
Your bodily fluids and tissues may be tested. This can be done with:
Images may be taken of your bodily structures. This can be done with a CT scan.

Treatment

HCL is a slow-growing cancer. As HCL progresses, treatment may include:
  • Surgery— A splenectomy may need to be done to remove an enlarged spleen.
  • Chemotherapy —This is the use of drugs to kill cancer cells. It may be given in many forms. This includes pill, injection, and via a catheter. The drugs enter the bloodstream and travel through the body.
  • Medications, such as cladribine, pentostatin, and interferon, are used to fight the hairy cells.
  • Blood transfusion —A blood transfusion may be done to treat anemia.
  • Antibiotics or other medications to fight infection

Prevention

There are no guidelines for preventing HCL.

RESOURCES

American Cancer Society http://www.cancer.org

The Leukemia & Lymphoma Society http://www.leukemia.org

CANADIAN RESOURCES

BC Cancer Agency http://www.bccancer.bc.ca

Canadian Cancer Society http://www.cancer.ca

References

General information about hairy cell leukemia. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/hairy-cell-leukemia/Patient. Updated October 30, 2013. Accessed November 26, 2013.

Hairy cell leukemia. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated October 5, 2012. Accessed November 26, 2013.

Hairy cell leukemia. The Leukemia & Lymphoma Society website. Available at: http://www.lls.org/#/diseaseinformation/leukemia/hairycellleukemia/. Accessed November 26, 2013.

Revision Information

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