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Seventh Annual Antonio Capone, MD Memorial Lecture. Supported by a generous grant from the Capone family.
Wednesday, May 24, 2017
Butler Hospital, Ray Conference Center, 12 - 1 p.m., Cost: $25

Butler Hospital
Ray Conference Center
345 Blackstone Boulevard
Providence, RI 02906

For questions, please call (401) 681-2817
The Agin Brain - Capone Lecture Series

Major Depressive Disorder (MDD) is a significant public health problem.

Dr. Zubenko will discuss how he created the first etiology-based recombinant mouse model of this disorder, beginning at its biological roots. This work has deepened our understanding of the pathophysiology of MDD, provides an opportunity for better understanding the mechanisms of action of current treatments, and has laid the groundwork for developing more effective interventions for preventing and treating MDD and related disorders. These mice exhibit several features that are reminiscent of the human disorder, including alterations of brain anatomy and behavior. In addition, they identify functional gene expression pathways that suggest a converging pathophysiology for MDD and co-morbid disorders including heart disease, diabetes and Alzheimer's disease. Drawing on the three decades Dr. Zubenko has spent as a pioneer in psychiatry and clinical neuroscience and mentor to many of the most important clinical and academic faculty in the field of geriatric psychiatry, this talk will use the challenges of understanding and treating MDD as a model for a broader understanding of the modern practice of psychiatry and its integration with other medical disciplines.


George S. Zubenko, MD, PhD, is an accomplished academic psychiatrist and clinical neuroscientist who pioneered multidisciplinary approaches to the field of brain research before the term “translational research” became popular.

George S Zubenko, MD, PhDA long-time professor of psychiatry at the University of Pittsburgh, Dr. Zubenko is now an adjunct professor in the Department of Biological Sciences at Carnegie Mellon University and a principal in Keystone Advanced Behavioral Healthcare LLC in Wexford, Penn.

He earned a bachelor’s degree in biological sciences with honors from Carnegie Mellon, a medical degree, cum laude, from the University of Pittsburgh School of Medicine, and a doctorate in biological sciences (genetics) from Carnegie Mellon. He completed his internship in internal medicine at Mount Auburn Hospital, a residency in neurology at Massachusetts General Hospital, and a residency in psychiatry at McLean Hospital.

Dr. Zubenko’s contributions as a clinician, investigator and teacher/ mentor fostered the emergence of geriatric psychiatry as a recognized clinical specialty. He was among the first Diplomates of the American Board of Psychiatry and Neurology to be certified “with added qualifications in geriatric psychiatry.” He has been a prolific author of influential publications, a frequent peer reviewer of manuscripts and research proposals, a valued member of academic leadership groups, and an invited speaker at academic institutions and professional meetings in the United States and abroad.

Dr. Zubenko is a Distinguished Life Fellow of the American Psychiatry Association, and a Fellow of the American College of Neuropsychopharmacology and the American Association for the Advancement of Science. He is a founding member of the International College of Geriatric Psychoneuropharmacology.

Learning Objectives

At the conclusion of this lecture, participants will be able to:

  • Describe unique challenges to discovery of the pathophysiology of psychiatric disorders.
  • Identify the ways in which these challenges are an obstacle to the development of effective treatments.
  • Describe how minute changes in the genome can contribute to the development of both MDD and comorbid systemic conditions.

Continuing Education Credits

PHYSICIANS: Butler Hospital is accredited by the Rhode Island Medical Society to provide continuing medical education for physicians. Butler Hospital designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

NURSES: Butler Hospital is an approved provider of nursing continuing education by the NE_MSD, an accredited approver by the American Nurses' Credentialing Center's Commission on Accreditation. This program is designated for 1.0 contact hour.

SOCIAL WORKERS: Application for 1.0 continuing education credits has been made to the Rhode Island Chapter of the National Association of Social Workers CEU Collaborative.

MENTAL HEALTH COUNSELORS: This program is pending approval for 1.0 contact hours for Mental Health Counselors and Marriage and Family Therapists.